"Fixed" Kcentra Dosing May Expedite Warfarin Reversal

You may see orders for "fixed" doses of Kcentra...to emergently reverse the effects of warfarin.

The usual dose of this prothrombin complex concentrate is 25 to 50 units/kg...depending on how high warfarin has increased a patient's INR.

But giving a fixed 1,000 or 1,500 unit dose can simplify ordering and prep...and help patients get faster treatment if their INR isn't known.

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