Meds That Should Not Be Crushed

full update April 2025

Crushing pills can improve ease of administration, but some shouldn’t be crushed. Crushing extended-release meds can result in administration of a large dose all at once. Crushing delayed-release meds can alter the mechanism designed to protect the drug from gastric acids or prevent gastric mucosal irritation. Crushing sublingual or buccal tabs can alter effectiveness. Crushing pills based on certain technologies (i.e., amorphous solid dispersion or nanocrystals) can alter bioavailability.⁹ Crushing bitter-tasting meds can be unpleasant for the patient. Crushing irritating or hazardous meds can be harmful to the individual crushing the meds. If hazardous meds [e.g., carcinogenic] must be crushed, follow USP Chapter <800> standards in healthcare settings or advising outpatients on proper procedures. Hazardous meds below explicitly state not to crush in the product information. The NIOSH hazardous meds list is at https://www.cdc.gov/niosh/docs/2025-103/pdfs/2025-103.pdf?id=10.26616/NIOSHPUB2025103.

This table has some common meds that should not be crushed; many more may not be listed. Brand names are representative and may not be all-inclusive. The most current product labeling for US and Canadian products was used to confirm information, in addition to listed references.

Modified-release: Indicates extended-release or delayed-release formulation.⁷

Medications That Should Not Be Crushed^{1,3-5,10,13,14,22}
Generic Name	Brand Name	Dosage Form	Comments
Acamprosate	Campral (brand discontinued)	Tablet	Modified-release
Acetaminophen	Tylenol Arthritis Pain Extended-Release (US)	Tablet	Modified-release
Acoramidis	Attruby	Tablet	No information on the effects of crushing
Adagrasib	Krazati (US)	Tablet	Risk of instability; contact manufacturer for crushing instructions¹
Alendronate	Fosamax	Tablet	Irritant (oropharyngeal)
Alfuzosin	Uroxatral (US), Xatral (Canada)	Tablet	Modified-release
Alprazolam	Xanax XR (US)	Tablet	Modified-release
Ambrisentan	Letairis (US), Volibris (Canada)	Tablet	Risk of fetal harm and impaired fertility
Amoxicillin/Clavulanate	Augmentin XR (US; brand discontinued)	Tablet	Modified-release Scored tablets can be split
Aprepitant	Emend (US)	Capsule	Nanocrystal⁹
Asciminib	Scemblix	Tablet	Potential for altered release or absorption due to salt form conversion¹
Aspirin	Ecotrin	Tablet	Modified-release Irritant (gastric)
Aspirin/Dipyridamole	Aggrenox (US; brand discontinued)	Capsule	Modified-release
Atogepant	Qulipta	Tablet	May be an amorphous solid disperson¹
Atomoxetine	Strattera	Capsule	Irritant (ocular)
Avacopan	Tavneos	Capsule	May be an amorphous solid disperson¹
Avapritinib	Ayvakit	Tablet	Potential for altered release or absorption due to changes in crystalline form or particle size¹
Belumosudil	Rezurock	Tablet	Potential for altered release or absorption due to salt form conversion¹
Benzonatate	Tessalon Perles (US)	Capsule	Local anesthetic effect could increase the risk of choking
Bexagliflozin	Brenzavvy (US)	Tablet	Modified-release²⁰
Bisacodyl	Dulcolax	Tablet	Modified-release Irritant (gastric)
Brivaracetam	Briviact (US), Brivlera (Canada)	Tablet	Bad taste¹⁰
Bosutinib	Bosulif	Tablet	Riks of fetal harm and impaired fertility
Budesonide	Entocort EC (US), Entocort (Canada)	Capsule	Modified-release Can be opened for administration of intact granules
Budesonide	Uceris (US)	Tablet	Modified-release
Buprenorphine	Belbuca (US)	Film	Sublingual dosage form
Bupropion	Aplenzin (US), Forfivo XL (US), Wellbutrin SR (US), Wellbutrin XL, Zyban	Tablet	Modified-release
Cabozantinib	Cabometyx, Cometriq (US)	Capsule, Tablet	Risk of fetal harm and impaired fertility
Capivasertib	Truqap	Tablet	No information on the effects of crushing
Capmatinib	Tabrecta	Tablet	Potential for altered release or absorption due to salt form conversion¹
Carbamazepine	Carbatrol (US), Equetro (US)	Capsule	Modified-release Can be opened for administration of intact granules
Carbamazepine	Tegretol XR (US), Tegretol CR (Canada)	Tablet	Modified-release
Carvedilol	Coreg CR (US; brand discontinued)	Capsule	Modified-release Can be opened for administration of intact granules
Cefuroxime	Ceftin (brand discontinued)	Tablet	Bad taste
Ciprofloxacin	Cipro (US; brand discontinued in Canada)	Tablet	Bad taste
Ciprofloxacin	Cipro XR (US); Cipro XL (Canada; brand discontinued0	Tablet	Modified-release
Clarithromycin	Biaxin XL	Tablet	Modified-release
Clonidine	Kapvay (US)	Tablet	Modified-release
Colestipol	Colestid	Tablet	Choking hazard
Cyclobenzaprine	Amrix (US)	Capsule	Modified-release
Cyclophosphamide	Cytoxan (US), Procytox (Canada)	Capsule (US), Tablet	Carcinogenic Cytotoxic Risk of fetal harm and impaired fertility
Dabigatran	Pradaxa	Capsule	Intact product must be taken to avoid increased exposure (bioavailability)
Dalfampridine	Ampyra (US)	Tablet	Modified-release
Darifenacin	Enablex	Tablet	Modified-release
Dasatinib	Sprycel	Tablet	Riks of fetal harm and impaired fertility
Deferasirox	Exjade	Tablet	Tablet is for oral suspension
Desvenlafaxine	Pristiq	Tablet	Modified-release
Dexlansoprazole	Dexilant	Capsule	Modified-release Can be opened for administration of intact granules
Dexmethylphenidate	Focalin XR (US)	Capsule	Modified-release Can be opened for administration of intact granules
Dextroamphetamine	Dexedrine Spansule	Capsule	Modified-release Can be opened for administration of intact granules⁵
Dextroamphetamine/ Amphetamine	Adderall XR	Capsule	Modified-release Can be opened for administration of intact granules
Diclofenac	Voltaren (brand discontinued)	Tablet	Modified-release Irritant (gastric)¹¹
Diclofenac/misoprostol	Arthrotec	Tablet	Modified-release Irritant (gastric)¹¹ Risk of fetal harm
Diclofenac	Voltaren XR (US: Brand discontinued), Voltaren SR (Canada)	Tablet	Modified-release
Diflunisal	Dolobid (US; brand discontinued)	Tablet	Irritant (gastric)⁵
Diltiazem	Cardizem CD (US), CardizemLA (US), CartiaXT (US), Dilt-XR (US), Tiazac, Tiazac XC (Canada)	Tablet, Capsule	Modified-release Can be opened for administration of intact granules (Tiazac)
Dimethyl Fumarate	Tecfidera	Capsule	Modified-release
Disopyramide	Norpace CR (US)	Capsule	Modified-release
Divalproex	Depakote Sprinkle (US)	Capsule	Modified-release Can be opened for administration of intact granules
Divalproex	Depakote (US), Depakote ER (US), Epival (Canada)	Tablet	Modified-release
Docusate Sodium	Colace	Capsule	Bad taste
Donepezil	Aricept (23 mg strength only [US])	Tablet	Intact product must be taken to avoid increased rate of absorption⁵
Doxazosin	Cardura XL (US)	Tablet	Modified-release
Doxycycline	Doryx (US), Apprilon (Canada)	Capsule, Tablet	Modified-release Scored tablets can be broken up, taking care not to crush the pellets.
Drospirenone/estetrol	Nextstellis	Tablet	Low-dose product with risk of instability¹
Duloxetine	Cymbalta	Capsule	Modified-release
Dutasteride	Avodart, Jalyn	Capsule	Risk of fetal harm and impaired fertility Irritant (oropharyngeal)
Elacestrant	Orserdu	Tablet	Crushing may alter bioavailability⁷
Elbasvir/Grazoprevir	Zepatier (US)	Tablet	Amorphous solid dispersion⁹
Elexacaftor/Tezacaftor/ Ivacaftor	Trikafta	Tablet	Amorphous solid dispersion⁹
Ensartinib	Ensacove (US)	Capsule	No information on the effects of opening capsules
Enzalutamide	Xtandi	Capsule	Risk of fetal harm and impaired fertility
Ergotamine	Ergomar (US)	Tablet	For sublingual administration
Erythromycin delayed-release	Ery-Tab (US)	Tablet	Modified-release
Erythromycin ethylsuccinate	E.E.S. (US)	Tablet	Bad taste¹⁸
Esomeprazole	Nexium	Capsule (US), Tablet (Canada)	Modified-release Capsule can be opened for administration of intact granules¹²
Esomeprazole/naproxen	Vimovo (brand discontinued in US)	Tablet	Modified-release
Eszopiclone	Lunesta (US)	Tablet	Bad taste
Etravirine	Intelence	Tablet	Amorphous solid dispersion⁹ Tablet may be dispersed in water Scored tablets can be split
Everolimus	Afinitor, Zortress (US)	Tablet	Amorphous solid dispersion⁹ Risk of fetal harm and impaired fertility
Felodipine	Plendil(brand discontinued in US)	Tablet	Modified-release
Fenofibrate	TriCor (US; brand drushingiscontinued)	Tablet	Nanocrystal⁹
Ferrous Sulfate	Feosol	Tablet	Mucosal ulceration²
Fesoterodine	Toviaz	Tablet	Modified-release
Fexofenadine/ Pseudoephedrine	Allegra-D	Tablet	Modified-release
Fezolinetant	Veozah	Tablet	Effect of crushing on pharmacokinetics is unknown¹⁹
Finasteride	Propecia, Proscar	Tablet	Risk of fetal harm
Fluoxetine	Prozac Weekly (US; brand discontinued)	Capsule	Modified-release
Fluvastatin	Lescol XL(US)	Tablet	Modified-release (Lescol XL)
Fluvoxamine	Luvox CR (US; brand discontinued)	Capsule	Modified-release
Futibatinib	Lytgobi (US)	Tablet	Low-dose product with risk of instability¹
Gabapentin	Gralise (US), Horizant (US)	Tablet	Modified-release
Galantamine	Razadyne ER (US; brand discontinued), Zunveyl (US), Reminyl ER (Canada; brand discontinued)	Capsule, Tablet	Modified-release
Gepirone	Exxua (US)	Tablet	Modified-release
Glecaprevir/Pibrentasvir	Mavyret	Tablet	Amorphous solid dispersion⁹
Glipizide	Glucotrol XL (US)	Tablet	Modified-release
Guaifenesin	Mucinex (US)	Tablet	Modified-release
Guaifenesin/ Dextromethorphan	Mucinex DM (US)	Tablet	Modified-release
Guaifenesin/ Pseudoephedrine	Mucinex D (US)	Tablet	Modified-release
Guanfacine	Intuniv (US), Intuniv XR (Canada)	Tablet	Modified-release
Hydroxyurea	Droxia (US; brand discontinued), Hydrea, Siklos (US)	Capsule, Tablet	Cytotoxic Risk of fetal harm and impaired fertility
Ibandronate	Boniva (US; brand discontinued)	Tablet	Irritant (oropharyngeal)
Ibuprofen	Advil, Motrin	Tablet	Bad taste⁴
Imatinib	Gleevec	Tablet	Irritant (gastrointestinal) Scored tablets can be split Can be dispersed in water Risk of fetal harm
Involisib	Itovebi (US)	Tablet	No information on the effects of crushing
Indomethacin	Indocin SR (US; brand discontinued)	Capsule	Modified-release Can be opened for administration of intact granules⁴
Iptacopan	Fabhalta	Capsule	No information on the effects of opening capsules
Isavuconazonium Sulfate	Cresemba	Capsule	Risk of instability or reduced absorption¹⁵
Isosorbide Mononitrate	Imdur (US; brand discontinued)	Tablet	Modified-release Scored tablets can be split
Isotretinoin	Absorica(US), Absorica LD, Accutane (Canada), Amnesteem (US), Claravis (US), Clarus (Canada), Epuris (Canada), Myorisan (US), Zenatane (US)	Capsule	Irritant (esophageal) Teratogenic
Itraconazole	Sporanox	Capsule	Amorphous solid dispersion⁹
Ivacaftor	Kalydeco	Tablet	Amorphous solid dispersion⁹
Ivosidenib	Tibsovo	Tablet	Amorphous solid dispersion⁹
Lamotrigine	Lamictal XR (US)	Tablet	Modified-release
Lansoprazole	Prevacid	Capsule	Modified-release Can be opened for administration of intact granules
Lansoprazole	Prevacid SoluTab (US), Prevacid FasTab (Canada)	Tablet	Should be dissolved in the mouth, not chewed
Lazertinib	Lazcluze	Tablet	No information on the effects of crushing
Lenalidomide	Revlimid	Capsule	Teratogenic
Lenacapavir	Sunleca	Tablet	Potential for altered release or absorption due to salt form conversion¹
Lenvatinib	Lenvima	Capsule	Risk of fetal harm and impaired fertility
Levetiracetam	Keppra	Tablet	Bad taste⁴
Levetiracetam	Keppra XR (US)	Tablet	Modified-release
Levodopa/Carbidopa	Sinemet CR	Tablet	Modified-release Scored tablets can be split
Levomilnacipran	Fetzima	Capsule	Modified-release
Lithium Carbonate	Lithobid(US), Lithmax (Canada)	Tablet	Modified-release
Lopinavir/Ritonavir	Kaletra	Tablet	Amorphous solid dispersion⁹ Reduced bioavailability with crushing⁸
Loratadine/ Pseudoephedrine	Claritin-D (US), Claritin Allergy and Sinus (Canada)	Tablet	Modified-release
Lovastatin	Altoprev (US)	Tablet	Modified-release
Lubiprostone	Amitiza	Capsule	Exposure of capsule contents will impair absorption²⁵
Lumacaftor/Ivacaftor	Orkambi	Tablet	Amorphous solid dispersion⁹
Mavorixafor	Xolremdi	Capsules	No information of the effects of opening capsules
Memantine	Namenda XR (US)	Capsule	Modified-release Can be opened for administration of intact granules
Mesalamine (mesalazine)	Apriso (US), Asacol HD (US; brand discontinued), Delzicol (US; brand discontinued), Lialda (US), Mezavant (Canada), Octasa (Canada), Pentasa	Tablet, Capsule	Modified-release Capsules can be opened for administration of intact granules (Delzicol, Pentasa)
Metformin	Fortamet (US), Glucophage XR (US; brand discontinued), Glumetza	Tablet	Modified-release
Methylphenidate	Aptensio XR (US),Biphentin (Canada), Metadate CD (US), Foquest (Canada),Jornay PM, Metadate CD, Ritalin LA (US)	Capsule	Modified-release Can be opened for administration of intact granules
Methylphenidate	Concerta, Cotempla XR-ODT (US), Relexxii (US), Ritalin SR(Canada; brand discontinued)	Tablet	Modified-release
Metoprolol Succinate	Toprol-XL (US)	Tablet	Modified-release Scored tablets can be split
Miltefosine	Impavido	Capsule	Teratogenic Risk of impaired fertility
Minocycline	Emrosi (US), Solodyn (US; brand discontinued)	Capsule, Tablet	Modified-release
Mirabegron	Myrbetriq	Tablet	Modified-release
Momelotinib	Ojjaara	Tablet	No information on the effects of crushing
Morphine Sulfate	Avinza (US; brand discontinued); Kadian (Canada; brand discontinued in US)	Capsule	Modified-release Can be opened for administration of intact granules
Morphine Sulfate	MS Contin	Tablet	Modified-release
Mycophenolate	CellCept	Capsule, Tablet	Teratogenic Immunosuppressive
Mycophenolic Acid	Myfortic	Tablet	Modified-release Teratogenic Immunosuppressive
Naproxen	EC Naprosyn (US), Naprelan(US), Pro-naproxen EC (Canada), Teva-naproxen EC (Canada)	Tablet	Modified-release
Nevirapine	Viramune XR(US)	Tablet	Modified-release
Niacin	Niaspan (US; brand discontinued)	Tablet	Modified-release
Nicotine	Nicorette (US)	Lozenge	Should be dissolved in the mouth, not chewed
Nifedipine	Adalat CC (US; brand discontinued), Adalat Oros (Canda), Procardia XL (US), Adalat XL (Canada)	Tablet	Modified-release
Nilotinib	Tasigna, Danziten (US)	Capsule	Modified-release Risk of fetal harm Can be opened for administration of intact granules
Nirmatrelvir/ritonavir	Paxlovid	Tablets	No information on the effects of crushing
Nirogacestat	Ogsiveo (US)	Tablet	In one clinical trial, could be dispersed in water (may not fully dissolve). OraSweet could be added.⁶
Nisoldipine	Sular (US)	Tablet	Modified-release
Nitroglycerin	Nitrostat	Tablet	Sublingual dosage form
Olaparib	Lynparza	Tablet	Amorphous solid dispersion⁹ Risk of fetal harm
Omaveloxolone	Skyclarys	Capsule	Can be opened for administration
Omeprazole	Prilosec (US), Losec (Canada)	Capsule, Tablet	Modified-release Capsule can be opened for administration of intact granules⁵
Opicapone	Ongentys (US)	Capsule	Potential for instability¹
Orphenadrine	Norflex ER (US)	Tablet	Modified-release
Oxybutynin	Ditropan XL (US; brand discontinued)	Tablet	Modified-release
Oxycodone	OxyContin (US), OxyNEO (Canada), Xtampza ER (US)	Capsule, Tablet	Modified-release
Oxymorphone	Opana ER (US; brand discontinued)	Tablet	Modified-release
Paliperidone	Invega	Tablet	Modified-release
Pancreatic Enzymes	Cotazym (Canada), Creon, Pancrease (Canada), Pancreaze (US), Pertzye (US), Viokace,Zenpep (US)	Capsule	Modified-release (capsules) Irritant (oral mucosal) Capsules can be opened for administration of intact granules
Pantoprazole	Protonix (US), Pantoloc (Canada)	Tablet	Modified-release
Paroxetine	Paxil CR	Tablet	Modified-release Risk of fetal harm and impaired fertility
Pazopanib	Votrient	Tablet	Increased absorption Risk of fetal harm and impaired fertility
Pentoxifylline	Trental (US; brand discontinued)	Tablet	Modified-release
Piroxicam	Feldene (US)	Capsule	Irritant (oropharyngeal)⁴
Pirtobrutinib	Jaypirca (US)	Tablet	Risk of fetal harm
Pomalidomide	Pomalyst	Capsule	Teratogenic
Posaconazole	Noxafil (US; brand discontinued), Posanol (Canada)	Tablet	Amorphous oral dispersion⁹ Modified-release
Potassium Chloride	Micro-K (US; brand discontinued)	Capsule	Modified-release Can be opened for administration of intact granules⁴
Potassium Chloride	Klor-Con (US), K-tab (US; brand discontinued)	Tablet	Modified-release
Potassium Chloride	Klor-Con (US; brand discontinued)	Capsule	Modified-release
Potassium Chloride	K-Dur (US; brand discontinued)	Tablet	Modified-release Scored tablet may be cut in half. May be dispersed in water.
Pralsetinib	Gavreto	Capsule	Potential for instability¹
Praziquantel	Biltricide (brand discontinued in US)	Tablet	Bad taste Scored tablets can be split
Propafenone	Rythmol SR (US; brand discontinued)	Capsule	Modified-release
Propranolol	Inderal LA (US), InnoPran XL (US), Lupin-propranolol LA (Canada)	Capsule	Modified-release
Pseudoephedrine	Sudafed 12 Hour (US)	Tablet	Modified-release
Pseudoephedrine/ Desloratadine	Clarinex D (US)	Tablet	Modified-release
Pseudoephedrine/ Fexofenadine	Allegra D	Tablet	Modified-release
Pyridostigmine	Mestinon Timespan (US), Mestinon SR (Canada)	Tablet	Modified-release
Quetiapine	Seroquel XR	Tablet	Modified-release
Quizartinib	Vanflyta	Tablet	In one clinical trial, tablets could be dissolved in water²¹
Rabeprazole	Aciphex (US), Aciphex Sprinkle (US), Pariet (Canada)	Capsule, Tablet	Modified-release
Raloxifene	Evista	Tablet	Bad taste⁴ Risk of fetal harm Evidence of tumors at low doses in lab studies¹⁴
Ranolazine	Ranexa (US; brand discontinued), Corzyna (Canada)	Tablet	Modified-release
Regorafenib	Stivarga	Tablet	Amorphous solid dispersion⁹ Risk of fetal harm and impaired fertility
Reptrectinib	Augtyro (US)	Capsule	No information on the effects of opening capsules
Ripretinib	Qinlock	Tablet	May be an amorphous solid disperson¹
Risedronate	Actonel	Tablet	Irritant (oropharyngeal)
Risedronate	Atelvia (US), Actonel DR (Canada)	Tablet	Modified-release Irritant (oropharyngeal)
Risperidone	Risperdal M-Tab (US; brand discontinued)	Tablet	Must be allowed to dissolve on the tongue
Ritlecitinib	Litfulo	Capsule	No information on the effects of opening capsules
Ritonavir	Norvir	Tablet	Amorphous solid dispersion⁹
Ropinirole	Requip XL (US; brand discontinued)	Tablet	Modified-release
Selumetinib	Koselugo	Capsules	Special dosage form (semi-solid fill content) suggests bioavailability may be altered if crushed¹
Sirolimus	Rapamune	Tablet	Nanocrystal⁹
Solifenacin	Vesicare	Tablet	Bad taste
Sotagliflozin	Inpefa	Tablet	No information on the effects of crushing
Sulfasalazine	Azulfidine EN-Tabs (US), Salazopyrin EN (Canada)	Tablet	Modified-release
Suvorexant	Belsomra (US)	Tablet	Amorphous solid dispersion⁹
Suzetrigine	Journavx (US)	Tablet	Can be dispersed in a small amount of water for immediate administration.²⁴
Tacrolimus	Astagraf XL (US), Prograf	Capsule	Amorphous solid dispersion⁹
Tamsulosin	Flomax (US; brand discontinued), Flomax CR (Canada; brand discontinued)	Capsule, Tablet	Modified-release Capsule may be opened for administration of intact beads.¹⁶
Tapentadol	Nucynta ER	Tablet	Modified-release
Temozolomide	Temodar (US; brand discontinued), Temodal (Canada)	Capsule	Cytotoxic Risk of fetal harm and impaired fertility
Tezacaftor/Ivacaftor	Symdeko	Tablet	Amorphous solid dispersion⁹
Theophylline	Theo-24 (US)	Capsule	Modified-release Can be opened for administration of intact granules
Theophylline	Theo-ER (Canada), Uniphyl (US; brand discontinued), Theo-Dur (US; brand discontinued)	Tablet	Modified-release
Tipranavir	Aptivus	Capsule	Bad taste⁴
Tolterodine	Detrol LA	Capsule	Modified-release
Topiramate	Topamax	Capsule, Tablet	Bad taste Capsules can be opened for administration of intact granules
Topiramate	Qudexy XR (US), Trokendi XR (US)	Capsule	Modified-release Can be opened for administration of intact granules (Qudexy XR)
Tramadol	ConZip (US), Ultram ER (US; brand discontinued), Zytram XL (Canada)	Capsule, Tablet	Modified-release
Trazodone	Desyryl (brand discontinued)	Tablet	Bad taste⁵ Scored tablets can be split
Tucatinib	Tukysa	Tablet	May be an amorphous solid disperson¹
Vadadustat	Vafseo (US)	Tablet	No information on the effects of crushing
Valganciclovir	Valcyte	Tablet	Irritant¹⁷ Risk fetal harm and impaired fertility Carcinogenic
Valproic Acid	Depakene (brand discontinued)	Capsule	Irritant (oropharyngeal)
Vandetanib	Caprelsa	Tablet	Tablet may be dispersed in water. Risk of fetal harm and impaired fertility
Vemurafenib	Zelboraf	Tablet	Amorphous solid dispersion⁹
Venetoclax	Venclexta	Tablet	Amorphous solid dispersion⁹
Venlafaxine	Effexor XR	Capsule	Modified-release Can be opened for administration of intact granules
Verapamil	Verelan(US), Verelan PM (US)	Capsule	Modified-release Can be opened for administration of intact granules
Verapamil	Isoptin SR (brand discontinued in US)	Tablet	Modified-release Scored tablets can be split
Vimseltinib	Romvimza (US)	Capsule	No information on the effects of opening capsules
Vismodegib	Erivedge	Capsule	Teratogenic
Voclosporin	Lupkynis	Capsule	Special dosage form (one-piece soft gelatin capsule) suggests bioavailability may be altered if crushed¹
Vorasidenib	Voranigo	Tablet	No information on the effects of crushing
Vorinostat	Zolinza	Capsule	Risk of fetal harm and impaired fertility
Xanomeline/trospium	Cobenfy (US)	Capsule	No information on effects of opening capsules
Zileuton	Zyflo CR (US; brand discontinued)	Tablet	Modified-release
Zolpidem	Ambien CR (US)	Tablet	Modified-release
Zolpidem	Edluar (US), Intermezzo (US; brand discontinued)	Tablet	Sublingual dosage form

References

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Cite this document as follows: Clinical Resource, Meds That Should Not Be Crushed. Pharmacist’s Letter/Pharmacy Technician’s Letter/Prescriber Insights. March 2025. [410460]

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