Stay Alert for Lybalvi, a New Combo Antipsychotic

Rx Lybalvi combines the antipsychotic olanzapine with samidorphan, a new opioid antagonist...for schizophrenia or bipolar disorder.

Samidorphan is derived from naltrexone. But so far, using it alone hasn't panned out for alcohol use disorder or other conditions.

In Lybalvi, the idea is that samidorphan may lessen weight gain from olanzapine...possibly by blocking opioid receptors that regulate appetite.